loading...| Preferred Name |
Doxycycline |
|
| Synonyms |
Doxycycline Monohydrate DOXYCYCLINE doxycycline Doxycycline |
|
| Definitions |
A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C457 |
|
| ALT_DEFINITION |
A drug used to treat many types of bacterial infections. It stops the growth of bacteria by keeping them from making proteins. It is a type of antibiotic. |
|
| CAS_Registry |
17086-28-1 |
|
| CHEBI_ID |
CHEBI:60648 |
|
| Chemical_Formula |
C22H24N2O8.H2O |
|
| code |
C457 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. |
|
| Display_Name |
Doxycycline |
|
| FDA_UNII_Code |
N12000U13O |
|
| FULL_SYN |
Doxycycline Monohydrate DOXYCYCLINE doxycycline Doxycycline |
|
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102526 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29010 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98040 |
|
| label |
Doxycycline |
|
| Legacy Concept Name |
Doxycycline |
|
| NCI_Drug_Dictionary_ID |
42494 |
|
| PDQ_Closed_Trial_Search_ID |
42494 |
|
| PDQ_Open_Trial_Search_ID |
42494 |
|
| Preferred_Name |
Doxycycline |
|
| prefixIRI |
Thesaurus:C457 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
| UMLS_CUI |
C0013090 |
|
| subClassOf |