National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Lamotrigine

Synonyms

Lamictal

LAMOTRIGINE

lamotrigine

Lamotrigine

Definitions

A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38703

Accepted_Therapeutic_Use_For

Epilepsy

ALT_DEFINITION

A drug that is used to help control some types of seizures. It is being studied in the prevention of peripheral neuropathy caused by some chemotherapy drugs. It belongs to the family of drugs called anticonvulsants.

CAS_Registry

84057-84-1

CHEBI_ID

CHEBI:6367

Chemical_Formula

C9H7Cl2N5

code

C38703

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)

DesignNote

Clinical Trial--Chemotherapy-induced neuropathy

FDA_UNII_Code

U3H27498KS

FULL_SYN

Lamictal

LAMOTRIGINE

lamotrigine

Lamotrigine

label

Lamotrigine

Legacy_Concept_Name

Lamotrigine

PDQ_Closed_Trial_Search_ID

328241

PDQ_Open_Trial_Search_ID

328241

Preferred_Name

Lamotrigine

prefixIRI

ncit:C38703

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0064636

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C264

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http://purl.bioontology.org/ontology/LNC/LP17251-7 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060528 LOINC LOOM
http://scai.fraunhofer.de/MSOntology#Lamotrigine MSO LOOM
http://purl.bioontology.org/ontology/VANDF/4020896 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148390 NDFRT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000328241 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/28439 RXNORM LOOM
http://purl.bioontology.org/ontology/CPT/80175 CPT LOOM
http://purl.bioontology.org/ontology/NDDF/003988 NDDF LOOM
http://purl.bioontology.org/ontology/UATC/N03AX09 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0064636 OCHV LOOM
http://www.drugbank.ca/drugs/DB00555 FTC LOOM
http://www.co-ode.org/ontologies/galen#Lamotrigine GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387562000 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906050879505783 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-61170 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D000077213 MESH LOOM
http://stirdf.jst.go.jp/id/200907015386390689 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14273 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/dnf.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047781 RH-MESH LOOM
http://www.case.edu/EpSO.owl#Lamotrigine EPSO LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 DRON LOOM