loading...| Preferred Name |
Azathioprine |
|
| Synonyms |
AZATHIOPRINE Azathioprine 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZA AZTP |
|
| Definitions |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C290 |
|
| CAS_Registry |
446-86-6 |
|
| CHEBI_ID |
CHEBI:2948 |
|
| Chemical_Formula |
C9H7N7O2S |
|
| code |
C290 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
|
| FDA_UNII_Code |
MRK240IY2L |
|
| FULL_SYN |
AZATHIOPRINE Azathioprine 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine AZA AZTP |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Azathioprine |
|
| Legacy Concept Name |
Azathioprine |
|
| Maps_To |
Azathioprine |
|
| NSC Number |
39084 |
|
| Preferred_Name |
Azathioprine |
|
| prefixIRI |
Thesaurus:C290 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0004482 |
|
| subClassOf |