loading...| Preferred Name |
Calcipotriene |
|
| Synonyms |
CALCIPOTRIENE Calcipotriol Calcipotriene Dovonex |
|
| Definitions |
A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28900 |
|
| CAS_Registry |
112965-21-6 112828-00-9 |
|
| CHEBI_ID |
CHEBI:50749 |
|
| Chemical_Formula |
C27H40O3 |
|
| code |
C28900 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04) |
|
| Display_Name |
Calcipotriene |
|
| FDA_UNII_Code |
143NQ3779B |
|
| FULL_SYN |
CALCIPOTRIENE Calcipotriol Calcipotriene Dovonex |
|
| label |
Calcipotriene |
|
| Legacy Concept Name |
Calcipotriene |
|
| NCI_Drug_Dictionary_ID |
752368 |
|
| PDQ_Closed_Trial_Search_ID |
752368 |
|
| PDQ_Open_Trial_Search_ID |
752368 |
|
| Preferred_Name |
Calcipotriene |
|
| prefixIRI |
Thesaurus:C28900 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0065767 |
|
| subClassOf |