National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Azithromycin

Synonyms

CP 62993

Azithromycin

XZ-450

AzaSite

N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A

Zithromax

AZITHROMYCIN, UNSPECIFIED FORM

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentade

Definitions

An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28844

CAS_Registry

83905-01-5

code

C28844

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death.

Display_Name

Azithromycin

FDA_UNII_Code

F94OW58Y8V

FULL_SYN

CP 62993

Azithromycin

XZ-450

AzaSite

N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A

Zithromax

AZITHROMYCIN, UNSPECIFIED FORM

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentade

label

Azithromycin

Legacy_Concept_Name

Azithromycin

NSC_Code

643732

PDQ_Closed_Trial_Search_ID

695416

PDQ_Open_Trial_Search_ID

695416

Preferred_Name

Azithromycin

prefixIRI

ncit:C28844

Semantic_Type

Antibiotic

UMLS_CUI

C0052796

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C261

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http://purl.obolibrary.org/obo/CHEBI_2955 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2955 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.505.250.050 RH-MESH LOOM
http://purl.jp/bio/4/id/200906085419270077 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4020019 VANDF LOOM
http://purl.obolibrary.org/obo/ARO_3000158 ARO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13540 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D017963 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017963 RH-MESH LOOM
http://www.owl-ontologies.com/assert.owl#Azithromycin ONTOKBCF LOOM
http://purl.bioontology.org/ontology/SNMI/C-52A20 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006795 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/4006-0007 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/S01AA26 ATC LOOM
http://www.co-ode.org/ontologies/galen#Azithromycin GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/003635 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387531004 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0052796 OCHV LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000695416 PDQ LOOM
http://purl.bioontology.org/ontology/UATC/J01FA10 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148074 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/e93.. RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/18631 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907014382733739 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP16090-0 LOINC LOOM