National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Amoxicillin

Synonyms

amoxicillin

Amoxicillin Trihydrate

Amoxicillin

AMOXICILLIN

AMOX

Amoxil

Polymox

Trimox

Utimox

Wymox

Definitions

A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C237

ALT_DEFINITION

A drug used to treat some bacterial infections. Amoxicillin is a form of penicillin that is made in the laboratory. It kills certain types of bacteria. It is a type of antibiotic.

CAS_Registry

61336-70-7

CHEBI_ID

CHEBI:51254

Chemical_Formula

C16H19N3O5S.3H2O

code

C237

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

HemOnc

DEFINITION

A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

804826J2HU

FULL_SYN

amoxicillin

Amoxicillin Trihydrate

Amoxicillin

AMOXICILLIN

AMOX

Amoxil

Polymox

Trimox

Utimox

Wymox

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72700

label

Amoxicillin

Legacy Concept Name

Amoxicillin

NCI_Drug_Dictionary_ID

42310

NSC Number

277174

PDQ_Closed_Trial_Search_ID

42310

PDQ_Open_Trial_Search_ID

42310

Preferred_Name

Amoxicillin

prefixIRI

Thesaurus:C237

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0002645

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0001125 XCO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015926 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006036 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1044 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.260.825.750.050.050 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.737.750.050.050 RH-MESH LOOM
https://go.drugbank.com/drugs/DB01060 MDM LOOM
http://stirdf.jst.go.jp/id/200907030762519964 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C237 BERO LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Amoxicillin STMSO LOOM
http://purl.bioontology.org/ontology/VANDF/4017605 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.750.750.050.050 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D000658 BERO LOOM
http://purl.bioontology.org/ontology/SNMI/C-54620 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000658 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0002073 OMIT LOOM
http://purl.bioontology.org/ontology/LNC/LP15265-9 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372687004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/723 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/J01CA04 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002645 OCHV LOOM
http://purl.jp/bio/4/id/200906026078963374 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.750.750.050.050 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D000658 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145985 NDFRT LOOM
http://purl.obolibrary.org/obo/ARO_0000064 ARO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.750.750.050.050 RH-MESH LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00881 COID LOOM
http://www.limics.fr/ontologies/ontoparonmed#Clamoxyl ONTOPARON LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_2676 MCO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042310 PDQ LOOM