loading...| Preferred Name |
Acetaminophen |
|
| Synonyms |
ACETAMINOPHEN N-(4-Hydroxyphenyl)acetamide Acetaminophen acetaminophen Paracetamol 4-Hydroxyacetanilide APAP Tylenol |
|
| Definitions |
A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic activity may result from inhibition of prostaglandin synthesis and release in the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating center in the anterior hypothalamus. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C198 |
|
| ALT_DEFINITION |
A drug that reduces pain and fever (but not inflammation). It belongs to the family of drugs called analgesics. |
|
| CAS_Registry |
103-90-2 |
|
| CHEBI_ID |
CHEBI:46195 |
|
| Chemical_Formula |
C8H9NO2 |
|
| code |
C198 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic activity may result from inhibition of prostaglandin synthesis and release in the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating center in the anterior hypothalamus. |
|
| Display_Name |
Acetaminophen |
|
| FDA_UNII_Code |
362O9ITL9D |
|
| FULL_SYN |
ACETAMINOPHEN N-(4-Hydroxyphenyl)acetamide Acetaminophen acetaminophen Paracetamol 4-Hydroxyacetanilide APAP Tylenol |
|
| Is_Value_For_GDC_Property | ||
| label |
Acetaminophen |
|
| Legacy Concept Name |
Acetaminophen |
|
| Maps_To |
Acetaminophen |
|
| NCI_Drug_Dictionary_ID |
39129 |
|
| NSC Number |
109028 3991 |
|
| PDQ_Closed_Trial_Search_ID |
39129 |
|
| PDQ_Open_Trial_Search_ID |
39129 |
|
| Preferred_Name |
Acetaminophen |
|
| prefixIRI |
Thesaurus:C198 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0000970 |
|
| subClassOf |