loading...| Preferred Name | Biguanide Antidiabetic Agent | |
| Synonyms |
Biguanide Antidiabetic Agent Biguanide |
|
| Definitions |
Any antidiabetic agent with the biguanide base structure or phenformin derivatives with antihyperglycemic activity. Biguanide antidiabetic agents activate AMP-activated protein kinase (AMPK) resulting in decreased glucose production in the liver, increased peripheral glucose uptake and improved utilization of glucose. Biguanide-based antidiabetic agents do not cause hypoglycemia. In addition, biguanide antidiabetics decrease absorption of glucose from the gastrointestinal tract. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98234 |
|
| code |
C98234 |
|
| Concept_In_Subset | ||
| Contributing_Source |
GDC |
|
| DEFINITION |
Any antidiabetic agent with the biguanide base structure or phenformin derivatives with antihyperglycemic activity. Biguanide antidiabetic agents activate AMP-activated protein kinase (AMPK) resulting in decreased glucose production in the liver, increased peripheral glucose uptake and improved utilization of glucose. Biguanide-based antidiabetic agents do not cause hypoglycemia. In addition, biguanide antidiabetics decrease absorption of glucose from the gastrointestinal tract. |
|
| FULL_SYN |
Biguanide Antidiabetic Agent Biguanide |
|
| Is_Value_For_GDC_Property | ||
| label |
Biguanide Antidiabetic Agent |
|
| Maps_To |
Biguanide |
|
| Preferred_Name |
Biguanide Antidiabetic Agent |
|
| prefixIRI |
Thesaurus:C98234 |
|
| Semantic_Type |
Pharmacologic Substance Chemical Viewed Functionally |
|
| UMLS_CUI |
C3273895 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C98234 | BERO | LOOM |