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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Vidarabine | |
| Synonyms |
Araadenosine Spongoadenosine 9-Beta-D-arabinofuranosyladenine Monohydrate Arabinosyladenine 9-Beta-D-arabinofuranosyl-9H-purine-6-amine Monohydrate Adenine Arabinoside Ara-A Arasena-A Beta Ara-A CI-673 VIDARABINE Vidarabine Vira-A |
|
| Definitions |
A nucleoside analog with activity against herpes simplex virus and varicella zoster virus. Vidarabine is converted to a monophosphate by viral thymidine kinase and is further modified to a triphosphate form by host enzymes. Vidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C929 |
|
| CAS_Registry |
24356-66-9
|
|
| CHEBI_ID |
CHEBI:9978
|
|
| Chemical_Formula |
C10H13N5O4.H2O
|
|
| code |
C929
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A nucleoside analog with activity against herpes simplex virus and varicella zoster virus. Vidarabine is converted to a monophosphate by viral thymidine kinase and is further modified to a triphosphate form by host enzymes. Vidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication.
|
|
| FDA_UNII_Code |
FA2DM6879K
|
|
| FULL_SYN |
Araadenosine Spongoadenosine 9-Beta-D-arabinofuranosyladenine Monohydrate Arabinosyladenine 9-Beta-D-arabinofuranosyl-9H-purine-6-amine Monohydrate Adenine Arabinoside Ara-A Arasena-A Beta Ara-A CI-673 VIDARABINE Vidarabine Vira-A
|
|
| label |
Vidarabine
|
|
| Legacy Concept Name |
Vidarabine
|
|
| NCI_Drug_Dictionary_ID |
39150
|
|
| NSC Number |
404241
|
|
| PDQ_Closed_Trial_Search_ID |
39150
|
|
| PDQ_Open_Trial_Search_ID |
39150
|
|
| Preferred_Name |
Vidarabine
|
|
| prefixIRI |
Thesaurus:C929
|
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
|
|
| UMLS_CUI |
C0042646
|
|
| subClassOf |
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