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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Uracil Mustard | |
| Synonyms |
URACIL MUSTARD Uracil Mustard Uracil mustard 5-(bis-(2-Chloroethyl) Amino) Uracil 5-[Bis(2-chloroethyl)amino]uracil U 8344 U-8344 Uramustine |
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| Definitions |
An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such as cancer cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C918 |
|
| CAS_Registry |
66-75-1
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|
| CHEBI_ID |
CHEBI:9884
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|
| Chemical_Formula |
C8H11Cl2N3O2
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|
| code |
C918
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|
| Concept_In_Subset | ||
| Contributing_Source |
FDA HemOnc
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|
| DEFINITION |
An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such as cancer cells.
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|
| FDA_UNII_Code |
W7KQ46GJ8U
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|
| FULL_SYN |
URACIL MUSTARD Uracil Mustard Uracil mustard 5-(bis-(2-Chloroethyl) Amino) Uracil 5-[Bis(2-chloroethyl)amino]uracil U 8344 U-8344 Uramustine
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|
| label |
Uracil Mustard
|
|
| Legacy Concept Name |
Uracil_Mustard
|
|
| NSC Number |
34462
|
|
| Preferred_Name |
Uracil Mustard
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|
| prefixIRI |
Thesaurus:C918
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|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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|
| UMLS_CUI |
C0041920
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|
| subClassOf |
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