Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.

C91525

Trypanosoma cruzi Infection Pathway

Chagas disease (American trypanosomiasis)

Chagas Disease Pathway

Chagas disease

T. cruzi Infection Pathway

hsa05142

Chagas Disease Pathway

Chagas Disease Pathway

Thesaurus:C91525

Functional Concept

C2984330