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National Cancer Institute Thesaurus
| Preferred Name | Dabigatran Etexilate Mesylate | |
| Synonyms |
Dabigatran Etexilate Mesylate DABIGATRAN ETEXILATE MESYLATE Beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-,ethyl ester, methanesulfonate BIBR 1048 MS BIBR 1048MS Pradaxa |
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| Definitions |
An orally available mesylate salt form of the etexilate prodrug of dabigatran, a benzimidazole and direct thrombin inhibitor with anticoagulant activity. Upon administration, dabigatran etexilate is hydrolyzed by esterases and is converted into dabigatran. Dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90702 |
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| CAS_Registry |
593282-20-3 872728-81-9
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| Chemical_Formula |
C34H41N7O5.CH4O3S
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| code |
C90702
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
An orally available mesylate salt form of the etexilate prodrug of dabigatran, a benzimidazole and direct thrombin inhibitor with anticoagulant activity. Upon administration, dabigatran etexilate is hydrolyzed by esterases and is converted into dabigatran. Dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots.
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| FDA_UNII_Code |
SC7NUW5IIT
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| FULL_SYN |
Dabigatran Etexilate Mesylate DABIGATRAN ETEXILATE MESYLATE Beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-,ethyl ester, methanesulfonate BIBR 1048 MS BIBR 1048MS Pradaxa
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Dabigatran Etexilate Mesylate
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| NCI_Drug_Dictionary_ID |
763237
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| PDQ_Closed_Trial_Search_ID |
763237
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| PDQ_Open_Trial_Search_ID |
763237
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| Preferred_Name |
Dabigatran Etexilate Mesylate
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| prefixIRI |
Thesaurus:C90702
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C2343849
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| subClassOf |
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