loading...| Preferred Name |
Levothyroxine Sodium |
|
| Synonyms |
Therapeutic Levothyroxine LEVOTHYROXINE SODIUM Levothyroxine sodium Levothyroxine Sodium Thyroid hormone replacement Sodium levothyroxine Levothroid Synthroid |
|
| Definitions |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C888 |
|
| CAS_Registry |
25416-65-3 |
|
| Chemical_Formula |
C15H10I4NO4.Na.H2O |
|
| code |
C888 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186329 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
| Contributing_Source |
CTRP FDA GDC PCDC |
|
| DEFINITION |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. |
|
| Display_Name |
Levothyroxine Sodium |
|
| FDA_UNII_Code |
9J765S329G |
|
| FULL_SYN |
Therapeutic Levothyroxine LEVOTHYROXINE SODIUM Levothyroxine sodium Levothyroxine Sodium Thyroid hormone replacement Sodium levothyroxine Levothroid Synthroid |
|
| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Levothyroxine Sodium |
|
| Legacy Concept Name |
Therapeutic_Levothyroxine |
|
| Maps_To |
Levothyroxine Sodium |
|
| NCI_Drug_Dictionary_ID |
39298 |
|
| NSC Number |
36397 |
|
| PDQ_Closed_Trial_Search_ID |
39298 |
|
| PDQ_Open_Trial_Search_ID |
39298 |
|
| Preferred_Name |
Levothyroxine Sodium |
|
| prefixIRI |
Thesaurus:C888 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0079691 |
|
| subClassOf |