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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C888
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C888
|
|---|---|
| Preferred Name | Levothyroxine Sodium |
| Definitions |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects.
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| Synonyms |
Therapeutic Levothyroxine
LEVOTHYROXINE SODIUM
Levothyroxine sodium
Levothyroxine Sodium
Thyroid hormone replacement
Sodium levothyroxine
Levothroid
Synthroid
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Levothyroxine Sodium
|
|---|---|
| Maps_To |
Levothyroxine Sodium
|
| Legacy Concept Name |
Therapeutic_Levothyroxine
|
| NCI_Drug_Dictionary_ID |
39298
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
39298
|
| Preferred_Name |
Levothyroxine Sodium
|
| Display_Name |
Levothyroxine Sodium
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C888
|
| DEFINITION |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects.
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| UMLS_CUI |
C0079691
|
| code |
C888
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| Chemical_Formula |
C15H10I4NO4.Na.H2O
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| subClassOf | |
| NSC Number |
36397
|
| type | |
| CAS_Registry |
25416-65-3
|
| FULL_SYN |
Therapeutic Levothyroxine
LEVOTHYROXINE SODIUM
Levothyroxine sodium
Levothyroxine Sodium
Thyroid hormone replacement
Sodium levothyroxine
Levothroid
Synthroid
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|
| FDA_UNII_Code |
9J765S329G
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| PDQ_Open_Trial_Search_ID |
39298
|
| Contributing_Source |
CTRP
FDA
GDC
PCDC
|
| Concept_In_Subset |
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|
| Has_Free_Acid_Or_Base_Form |
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