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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Recombinant Thyroid-Stimulating Hormone | |
| Synonyms |
Recombinant Thyroid-Stimulating Hormone Thyrotropin Recombinant TSH THYROTROPIN Thyroid Stimulating Hormone Thytropar |
|
| Definitions |
A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C887 |
|
| CAS_Registry |
9002-71-5
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|
| code |
C887
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A recombinant form of the heterodimeric human anterior pituitary glycoprotein thyroid-stimulating hormone (TSH) with potential use in hormone replacement therapy. Recombinant TSH binds to TSH receptors on thyroid epithelial cells and stimulates TSH-dependent signaling pathways. This stimulates iodine uptake and organification, and induces synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4).
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| FDA_UNII_Code |
02KSI6Z9AK
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|
| FULL_SYN |
Recombinant Thyroid-Stimulating Hormone Thyrotropin Recombinant TSH THYROTROPIN Thyroid Stimulating Hormone Thytropar
|
|
| label |
Recombinant Thyroid-Stimulating Hormone
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|
| Legacy Concept Name |
Recombinant_Thyroid-Stimulating_Hormone
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|
| NCI_Drug_Dictionary_ID |
526653
|
|
| PDQ_Closed_Trial_Search_ID |
526653
|
|
| PDQ_Open_Trial_Search_ID |
526653
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|
| Preferred_Name |
Recombinant Thyroid-Stimulating Hormone
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|
| prefixIRI |
Thesaurus:C887
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C1535531
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|
| subClassOf |
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C887 | BERO | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000526653 | PDQ | LOOM |