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National Cancer Institute Thesaurus
| Preferred Name | Benralizumab | |
| Synonyms |
Benralizumab BENRALIZUMAB Anti-CD125 Humanized Monoclonal Antibody, IgG1-kappa BIW-8405 Fasenra KHK-4563 MEDI-563 |
|
| Definitions |
An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88594 |
|
| Accepted_Therapeutic_Use_For |
Asthma
|
|
| CAS_Registry |
1044511-01-4
|
|
| code |
C88594
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc
|
|
| DEFINITION |
An afucosylated, humanized monoclonal antibody against the alpha chain of the interleukin-5 receptor (IL-5Ra), with potential anti-asthmatic activity. Upon administration, benralizumab binds to IL-5Ra and elicits an antibody-directed cell cytotoxicity (ADCC) against IL-5Ra-expressing cells. This induces apoptosis in IL-5Ra-expressing cells and may reduce asthmatic episodes. IL-5Ra, expressed on both eosinophils and basophils, plays a key role in asthma.
|
|
| Display_Name |
Benralizumab
|
|
| FDA_UNII_Code |
71492GE1FX
|
|
| FULL_SYN |
Benralizumab BENRALIZUMAB Anti-CD125 Humanized Monoclonal Antibody, IgG1-kappa BIW-8405 Fasenra KHK-4563 MEDI-563
|
|
| Has_Target | ||
| label |
Benralizumab
|
|
| NCI_Drug_Dictionary_ID |
794137
|
|
| PDQ_Closed_Trial_Search_ID |
794137
|
|
| PDQ_Open_Trial_Search_ID |
794137
|
|
| Preferred_Name |
Benralizumab
|
|
| prefixIRI |
Thesaurus:C88594
|
|
| Semantic_Type |
Pharmacologic Substance Immunologic Factor
|
|
| UMLS_CUI |
C2982078
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|
| subClassOf |
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