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National Cancer Institute Thesaurus
Last uploaded:
June 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88323
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88323
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|---|---|
| Preferred Name | Burixafor |
| Definitions |
An orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.
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| Synonyms |
Phosphonic Acid, p-(2-(4-(6-Amino-2-(((trans-4-(((3-(cyclohexylamino)propyl)amino)methyl)cyclohexyl)methyl)amino)-4-pyrimidinyl)-1-piperazinyl)ethyl)-
BURIXAFOR
Burixafor
TG-0054
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Burixafor
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|---|---|
| prefixIRI | Thesaurus:C88323
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| code | C88323
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| DEFINITION | An orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.
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| Is_Value_For_GDC_Property | |
| Contributing_Source |
FDA
GDC
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| NCI_Drug_Dictionary_ID | 813325
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| FULL_SYN | Phosphonic Acid, p-(2-(4-(6-Amino-2-(((trans-4-(((3-(cyclohexylamino)propyl)amino)methyl)cyclohexyl)methyl)amino)-4-pyrimidinyl)-1-piperazinyl)ethyl)-
BURIXAFOR
Burixafor
TG-0054
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| NCI_META_CUI | CL413584
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| Maps_To | Burixafor
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| FDA_UNII_Code | 2G17Y0Q20G
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| Preferred_Name | Burixafor
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| type | |
| subClassOf | |
| Has_Salt_Or_Ester_Form | |
| CAS_Registry | 1191448-17-5
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| Concept_In_Subset |
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| Semantic_Type | Pharmacologic Substance
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