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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C844
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C844
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|---|---|
| Preferred Name | Streptonigrin |
| Definitions |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)
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| Synonyms |
Bruneomycin
STREPTONIGRIN
5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid
Rufocromomycin
Streptonigrin
5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid
BA-163
PC-501
STN
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Streptonigrin
|
|---|---|
| Maps_To |
Streptonigrin
|
| Legacy Concept Name |
Streptonigrin
|
| CHEBI_ID |
CHEBI:9287
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| NCI_Drug_Dictionary_ID |
39703
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID |
39703
|
| Preferred_Name |
Streptonigrin
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
|
| prefixIRI |
Thesaurus:C844
|
| DEFINITION |
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)
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| UMLS_CUI |
C0038427
|
| code |
C844
|
| Chemical_Formula |
C25H22N4O8
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| subClassOf | |
| NSC Number |
45383
83950
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| type | |
| CAS_Registry |
3930-19-6
|
| FULL_SYN |
Bruneomycin
STREPTONIGRIN
5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid
Rufocromomycin
Streptonigrin
5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid
BA-163
PC-501
STN
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|
| FDA_UNII_Code |
261Q3JB310
|
| PDQ_Open_Trial_Search_ID |
39703
|
| Contributing_Source |
FDA
GDC
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| Concept_In_Subset |
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