loading...| Preferred Name |
Proflavine Hemisulfate |
|
| Synonyms |
Proflavine Hemisulfate Acridine, 3,6-Diamino-, Sulfate (2:1) PROFLAVINE HEMISULFATE |
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| Definitions |
The hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84109 |
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| CAS_Registry |
1811-28-5 2058-34-6 |
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| Chemical_Formula |
2C13H11N3.H2SO4 |
|
| code |
C84109 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
The hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth. |
|
| Display_Name |
Proflavine Hemisulfate |
|
| FDA_UNII_Code |
27V8M747VB |
|
| FULL_SYN |
Proflavine Hemisulfate Acridine, 3,6-Diamino-, Sulfate (2:1) PROFLAVINE HEMISULFATE |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Proflavine Hemisulfate |
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| NCI_Drug_Dictionary_ID |
771566 |
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| PDQ_Closed_Trial_Search_ID |
771566 |
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| PDQ_Open_Trial_Search_ID |
771566 |
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| Preferred_Name |
Proflavine Hemisulfate |
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| prefixIRI |
Thesaurus:C84109 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0033295 |
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| subClassOf |