National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Lincosamide Antibiotic
Synonyms

Lincosamide Antibiotic
Definitions

Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82922
code

C82922
DEFINITION

Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death.
FULL_SYN

Lincosamide Antibiotic
label

Lincosamide Antibiotic
Legacy Concept Name

Lincosamide_Antibiotic
Preferred_Name

Lincosamide Antibiotic
prefixIRI

Thesaurus:C82922
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C2826567
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C784
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