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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Lincosamide Antibiotic | |
| Synonyms |
Lincosamide Antibiotic |
|
| Definitions |
Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82922 |
|
| code |
C82922
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| DEFINITION |
Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death.
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| FULL_SYN |
Lincosamide Antibiotic
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|
| label |
Lincosamide Antibiotic
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|
| Legacy Concept Name |
Lincosamide_Antibiotic
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| Preferred_Name |
Lincosamide Antibiotic
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| prefixIRI |
Thesaurus:C82922
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| Semantic_Type |
Chemical Viewed Functionally
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| UMLS_CUI |
C2826567
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| subClassOf |
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