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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82258
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82258
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|---|---|
| Preferred Name | Alpha-1-Proteinase Inhibitor Human |
| Definitions |
Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.
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| Synonyms |
.ALPHA.1-PROTEINASE INHIBITOR HUMAN
Prolastin-C
Alpha-1 Antitrypsin
Alpha-1-Proteinase Inhibitor Human
Alpha 1 Antitrypsin
Alpha-1-Antiproteinase
A1AT
A1PI
AAT
Aralast
Glassia
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Alpha-1-Proteinase Inhibitor Human
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|---|---|
| Legacy Concept Name |
Alpha-1-Proteinase_Inhibitor_Human
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| NCI_Drug_Dictionary_ID |
721983
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| PDQ_Closed_Trial_Search_ID |
721983
|
| Preferred_Name |
Alpha-1-Proteinase Inhibitor Human
|
| Display_Name |
Alpha-1-Proteinase Inhibitor Human
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| Semantic_Type |
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C82258
|
| DEFINITION |
Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily.
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| UMLS_CUI |
C0795657
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| code |
C82258
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| subClassOf | |
| type | |
| CAS_Registry |
9041-92-3
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| FULL_SYN |
.ALPHA.1-PROTEINASE INHIBITOR HUMAN
Prolastin-C
Alpha-1 Antitrypsin
Alpha-1-Proteinase Inhibitor Human
Alpha 1 Antitrypsin
Alpha-1-Antiproteinase
A1AT
A1PI
AAT
Aralast
Glassia
See more
See less
|
| FDA_UNII_Code |
F43I396OIS
|
| PDQ_Open_Trial_Search_ID |
721983
|
| Contributing_Source |
CTRP
FDA
|
| Concept_In_Subset |
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