loading...| Preferred Name |
Alpha-1-Proteinase Inhibitor Human |
|
| Synonyms |
.ALPHA.1-PROTEINASE INHIBITOR HUMAN Prolastin-C Alpha-1 Antitrypsin Alpha-1-Proteinase Inhibitor Human Alpha 1 Antitrypsin Alpha-1-Antiproteinase A1AT A1PI AAT Aralast Glassia |
|
| Definitions |
Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82258 |
|
| CAS_Registry |
9041-92-3 |
|
| code |
C82258 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily. |
|
| Display_Name |
Alpha-1-Proteinase Inhibitor Human |
|
| FDA_UNII_Code |
F43I396OIS |
|
| FULL_SYN |
.ALPHA.1-PROTEINASE INHIBITOR HUMAN Prolastin-C Alpha-1 Antitrypsin Alpha-1-Proteinase Inhibitor Human Alpha 1 Antitrypsin Alpha-1-Antiproteinase A1AT A1PI AAT Aralast Glassia |
|
| label |
Alpha-1-Proteinase Inhibitor Human |
|
| Legacy Concept Name |
Alpha-1-Proteinase_Inhibitor_Human |
|
| NCI_Drug_Dictionary_ID |
721983 |
|
| PDQ_Closed_Trial_Search_ID |
721983 |
|
| PDQ_Open_Trial_Search_ID |
721983 |
|
| Preferred_Name |
Alpha-1-Proteinase Inhibitor Human |
|
| prefixIRI |
Thesaurus:C82258 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0795657 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C783 |