National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Zoledronic Acid Anhydrous
Synonyms

Zoledronic Acid Anhydrous

ZOLEDRONIC ACID ANHYDROUS
Definitions

Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80120
CAS_Registry

118072-93-8
CHEBI_ID

CHEBI:46557
Chemical_Formula

C5H10N2O7P2
code

C80120
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
FDA_UNII_Code

70HZ18PH24
FULL_SYN

Zoledronic Acid Anhydrous

ZOLEDRONIC ACID ANHYDROUS
label

Zoledronic Acid Anhydrous
Legacy Concept Name

Zolendronic_Acid_Anhydrous
Preferred_Name

Zoledronic Acid Anhydrous
prefixIRI

Thesaurus:C80120
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C2700334
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C443
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