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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Propylthiouracil | |
| Synonyms |
6-Propyl-2-thiouracil 6-Propyl-2-Thiouracil Propylthiouracil PROPYLTHIOURACIL |
|
| Definitions |
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C781 |
|
| CAS_Registry |
51-52-5
|
|
| CHEBI_ID |
CHEBI:8502
|
|
| Chemical_Formula |
C7H10N2OS
|
|
| code |
C781
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
|
|
| FDA_UNII_Code |
721M9407IY
|
|
| FULL_SYN |
6-Propyl-2-thiouracil 6-Propyl-2-Thiouracil Propylthiouracil PROPYLTHIOURACIL
|
|
| label |
Propylthiouracil
|
|
| Legacy Concept Name |
Propylthiouracil
|
|
| NCI_Drug_Dictionary_ID |
39288
|
|
| NSC Number |
70461
|
|
| PDQ_Closed_Trial_Search_ID |
39288
|
|
| PDQ_Open_Trial_Search_ID |
39288
|
|
| Preferred_Name |
Propylthiouracil
|
|
| prefixIRI |
Thesaurus:C781
|
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
|
|
| UMLS_CUI |
C0033511
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|
| subClassOf |
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