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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Prochlorperazine | |
| Synonyms |
prochlorperazine 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine PROCHLORPERAZINE Prochlorperazine Compro RP 6140 SKF-4657 |
|
| Definitions |
A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C774 |
|
| Accepted_Therapeutic_Use_For |
Anxiety; Dizziness; Nausea and vomiting management; Psychosis
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|
| ALT_DEFINITION |
A drug used to prevent or reduce nausea and vomiting. It belongs to the family of drugs called antiemetics.
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|
| CAS_Registry |
58-38-8
|
|
| CHEBI_ID |
CHEBI:8435
|
|
| Chemical_Formula |
C20H24ClN3S
|
|
| code |
C774
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04)
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|
| Display_Name |
Prochlorperazine
|
|
| FDA_UNII_Code |
YHP6YLT61T
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|
| FULL_SYN |
prochlorperazine 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine PROCHLORPERAZINE Prochlorperazine Compro RP 6140 SKF-4657
|
|
| Has_Salt_Form | ||
| label |
Prochlorperazine
|
|
| Legacy Concept Name |
Prochlorperazine
|
|
| NCI_Drug_Dictionary_ID |
39564
|
|
| PDQ_Closed_Trial_Search_ID |
39564
|
|
| PDQ_Open_Trial_Search_ID |
39564
|
|
| Preferred_Name |
Prochlorperazine
|
|
| prefixIRI |
Thesaurus:C774
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0033229
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|
| subClassOf |
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