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National Cancer Institute Thesaurus
Last uploaded:
July 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C773
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C773
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|---|---|
| Preferred Name | Procarbazine Hydrochloride |
| Definitions |
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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| Synonyms |
Ibenzmethyzine hydrochloride
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride
Ro 4-6467/1
MIH hydrochloride
Ro 4 6467/1
Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride
Procarbazine Hydrochloride
p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI)
PCB hydrochloride
PROCARBAZINE HYDROCHLORIDE
PCB Hydrochloride
p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride
procarbazine hydrochloride
Matulane
NCI C01810
NCI-C01810
NCIC01810
Natulan
Natulanar
Natunalar
PCB
PCZ
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Procarbazine Hydrochloride
|
|---|---|
| Maps_To | Procarbazine Hydrochloride
|
| Accepted_Therapeutic_Use_For | Brain tumors; Hodgkins diseases; Non-Hodgkins lymphoma
|
| Legacy Concept Name | Procarbazine
|
| NCI_Drug_Dictionary_ID | 41607
|
| Is_Value_For_GDC_Property | |
| PDQ_Closed_Trial_Search_ID | 41607
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| Preferred_Name | Procarbazine Hydrochloride
|
| Display_Name | Procarbazine Hydrochloride
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| prefixIRI | Thesaurus:C773
|
| DEFINITION | The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
|
| UMLS_CUI | C0205909
|
| code | C773
|
| Chemical_Formula | C12H19N3O.HCl
|
| subClassOf | |
| NSC Number | 77213
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| type | |
| CAS_Registry | 366-70-1
|
| FULL_SYN |
Ibenzmethyzine hydrochloride
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride
Ro 4-6467/1
MIH hydrochloride
Ro 4 6467/1
Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride
Procarbazine Hydrochloride
p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI)
PCB hydrochloride
PROCARBAZINE HYDROCHLORIDE
PCB Hydrochloride
p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride
procarbazine hydrochloride
Matulane
NCI C01810
NCI-C01810
NCIC01810
Natulan
Natulanar
Natunalar
PCB
PCZ
See more
See less
|
| FDA_UNII_Code | XH0NPH5ZX8
|
| ALT_DEFINITION | A drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Matulane blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.
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| PDQ_Open_Trial_Search_ID | 41607
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| Contributing_Source |
CTRP
FDA
GDC
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| Concept_In_Subset |
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| Has_Free_Acid_Or_Base_Form |
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