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National Cancer Institute Thesaurus
| Preferred Name | Procarbazine Hydrochloride | |
| Synonyms |
Ibenzmethyzine hydrochloride N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride Ro 4-6467/1 MIH hydrochloride Ro 4 6467/1 Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride Procarbazine Hydrochloride p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI) PCB hydrochloride PROCARBAZINE HYDROCHLORIDE PCB Hydrochloride p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride procarbazine hydrochloride Matulane NCI-C01810 Natulan Natulanar Natunalar PCB PCZ |
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| Definitions |
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C773 |
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| Accepted_Therapeutic_Use_For |
Brain tumors; Hodgkins diseases; Non-Hodgkins lymphoma
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| ALT_DEFINITION |
A drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Matulane blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.
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| CAS_Registry |
366-70-1
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| Chemical_Formula |
C12H19N3O.HCl
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| code |
C773
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC
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| DEFINITION |
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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| Display_Name |
Procarbazine Hydrochloride
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| FDA_UNII_Code |
XH0NPH5ZX8
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| FULL_SYN |
Ibenzmethyzine hydrochloride N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride Ro 4-6467/1 MIH hydrochloride Ro 4 6467/1 Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride Procarbazine Hydrochloride p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI) PCB hydrochloride PROCARBAZINE HYDROCHLORIDE PCB Hydrochloride p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride procarbazine hydrochloride Matulane NCI-C01810 Natulan Natulanar Natunalar PCB PCZ
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| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Procarbazine Hydrochloride
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| Legacy Concept Name |
Procarbazine
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| Maps_To |
Procarbazine Hydrochloride
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| NCI_Drug_Dictionary_ID |
41607
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| NSC Number |
77213
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| PDQ_Closed_Trial_Search_ID |
41607
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| PDQ_Open_Trial_Search_ID |
41607
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| Preferred_Name |
Procarbazine Hydrochloride
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| prefixIRI |
Thesaurus:C773
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0205909
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| subClassOf |
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