National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cephaloridine
Synonyms

Cephaloridine

CEPHALORIDINE
Definitions

A semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76594
CAS_Registry

50-59-9
CHEBI_ID

CHEBI:3537
Chemical_Formula

C19H17N3O4S2
code

C76594
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

A semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity. Cephaloridine binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
FDA_UNII_Code

LVZ1VC61HB
FULL_SYN

Cephaloridine

CEPHALORIDINE
label

Cephaloridine
Legacy Concept Name

Cephaloridine
Preferred_Name

Cephaloridine
prefixIRI

Thesaurus:C76594
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0007727
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357
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