National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Azithromycin Monohydrate
Synonyms

Azithromycin Monohydrate

AZITHROMYCIN MONOHYDRATE
Definitions

The monohydrate form of azithromycin, an orally bioavailable azalide derived from erythromycin, and a member of a subclass of macrolide antibiotics, with anti-bacterial activity. Upon oral administration, azithromycin reversibly binds to the 23S rRNA of the 50S ribosomal subunit of the bacterial ribosome of susceptible microorganisms, thereby inhibiting the translocation step of protein synthesis by preventing the assembly of the 50S ribosomal subunit. This inhibits bacterial protein synthesis, inhibits cell growth and causes cell death.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76215
CAS_Registry

121470-24-4
Chemical_Formula

C38H72N2O12.H2O
code

C76215
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

The monohydrate form of azithromycin, an orally bioavailable azalide derived from erythromycin, and a member of a subclass of macrolide antibiotics, with anti-bacterial activity. Upon oral administration, azithromycin reversibly binds to the 23S rRNA of the 50S ribosomal subunit of the bacterial ribosome of susceptible microorganisms, thereby inhibiting the translocation step of protein synthesis by preventing the assembly of the 50S ribosomal subunit. This inhibits bacterial protein synthesis, inhibits cell growth and causes cell death.
Display_Name

Azithromycin Monohydrate
FDA_UNII_Code

JTE4MNN1MD
FULL_SYN

Azithromycin Monohydrate

AZITHROMYCIN MONOHYDRATE
label

Azithromycin Monohydrate
Legacy Concept Name

Azithromycin_Monohydrate
NCI_Drug_Dictionary_ID

810791
Preferred_Name

Azithromycin Monohydrate
prefixIRI

Thesaurus:C76215
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0886592
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C261
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