National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cilazapril Anhydrous
Synonyms

Cilazapril Anhydrous

CILAZAPRIL ANHYDROUS
Definitions

The anhydrous form of the pyridazine angiotensin-converting enzyme (ACE) inhibitor cilazapril with antihypertensive activity. As a prodrug cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76134
CAS_Registry

88768-40-5
Chemical_Formula

C22H31N3O5
code

C76134
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The anhydrous form of the pyridazine angiotensin-converting enzyme (ACE) inhibitor cilazapril with antihypertensive activity. As a prodrug cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
FDA_UNII_Code

8Q9454114Q
FULL_SYN

Cilazapril Anhydrous

CILAZAPRIL ANHYDROUS
label

Cilazapril Anhydrous
Legacy Concept Name

Cilazapril_Anhydrous
Preferred_Name

Cilazapril Anhydrous
prefixIRI

Thesaurus:C76134
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0886706
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C247
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