National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cefaclor Anhydrous
Synonyms

CEFACLOR ANHYDROUS

Cefaclor Anhydrous
Definitions

The anhydrous form of cefaclor, a beta-lactam, second-generation cephalosporin with antibacterial activity. Cefaclor binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76033
CAS_Registry

53994-73-3
CHEBI_ID

CHEBI:3478
Chemical_Formula

C15H14ClN3O4S
code

C76033
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The anhydrous form of cefaclor, a beta-lactam, second-generation cephalosporin with antibacterial activity. Cefaclor binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
FDA_UNII_Code

3Z6FS3IK0K
FULL_SYN

CEFACLOR ANHYDROUS

Cefaclor Anhydrous
label

Cefaclor Anhydrous
Legacy Concept Name

Cefaclor_Anhydrous
Preferred_Name

Cefaclor Anhydrous
prefixIRI

Thesaurus:C76033
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C2699131
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357
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