National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Hyoscyamine Sulfate
Synonyms

Cystospaz-M

Hyoscyamine Sulfate

HYOSCYAMINE SULFATE

Levsin

Definitions

The sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74575

CAS_Registry

6835-16-1

Chemical_Formula

2C17H23NO3.2H2O.H2SO4

code

C74575

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.

FDA_UNII_Code

F2R8V82B84

FULL_SYN

Cystospaz-M

Hyoscyamine Sulfate

HYOSCYAMINE SULFATE

Levsin

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29104

label

Hyoscyamine Sulfate

Legacy Concept Name

Hyoscyamine_Sulfate

Preferred_Name

Hyoscyamine Sulfate

prefixIRI

Thesaurus:C74575

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0004261

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29704

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