National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Parecoxib Sodium
Synonyms

PARECOXIB SODIUM

Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-, Sodium Salt

Parecoxib Sodium

Dynastat
Definitions

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73831
CAS_Registry

197502-82-2

198470-85-8
Chemical_Formula

C19H17N2O4S.Na
code

C73831
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.
FDA_UNII_Code

EB87433V6F
FULL_SYN

PARECOXIB SODIUM

Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-, Sodium Salt

Parecoxib Sodium

Dynastat
label

Parecoxib Sodium
Legacy Concept Name

Parecoxib_Sodium
NCI_Drug_Dictionary_ID

753381
PDQ_Closed_Trial_Search_ID

753381
PDQ_Open_Trial_Search_ID

753381
Preferred_Name

Parecoxib Sodium
prefixIRI

Thesaurus:C73831
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0915144
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C257
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