National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Hexaminolevulinate Hydrochloride
Synonyms

HEXAMINOLEVULINATE HYDROCHLORIDE

Hexaminolevulinate Hydrochloride

Cysview

Hexvix
Definitions

The hydrochloride salt form of hexaminolevulinate, a hexyl ester of the heme precursor 5-aminolevulinic acid (ALA) with potential photosensitizing activity. Hexaminolevulinate serves as a precursor of photoactive porphyrins (PAPs), particularly protoporphyrin IX (PpIX), which selectively accumulate in rapidly proliferating cells, such as those seen in tumor tissue. When exposed to blue light, PAPs are activated and emit red light thereby allowing tumor imaging.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73601
CAS_Registry

140898-91-5
Chemical_Formula

C11H21NO3.HCl
code

C73601
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

The hydrochloride salt form of hexaminolevulinate, a hexyl ester of the heme precursor 5-aminolevulinic acid (ALA) with potential photosensitizing activity. Hexaminolevulinate serves as a precursor of photoactive porphyrins (PAPs), particularly protoporphyrin IX (PpIX), which selectively accumulate in rapidly proliferating cells, such as those seen in tumor tissue. When exposed to blue light, PAPs are activated and emit red light thereby allowing tumor imaging.
Display_Name

Hexaminolevulinate Hydrochloride
FDA_UNII_Code

D4F329SL1O
FULL_SYN

HEXAMINOLEVULINATE HYDROCHLORIDE

Hexaminolevulinate Hydrochloride

Cysview

Hexvix
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26654
label

Hexaminolevulinate Hydrochloride
Legacy Concept Name

Hexaminolevulinate_Hydrochloride
NCI_Drug_Dictionary_ID

776656
PDQ_Closed_Trial_Search_ID

776656
PDQ_Open_Trial_Search_ID

776656
Preferred_Name

Hexaminolevulinate Hydrochloride
prefixIRI

Thesaurus:C73601
Semantic_Type

Indicator, Reagent, or Diagnostic Aid
UMLS_CUI

C1950837
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1937
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