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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72910
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72910
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|---|---|
| Preferred Name | Perindopril |
| Definitions |
A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
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| Synonyms |
Perindopril
(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid, 1-ethyl Ester
PERINDOPRIL
S-9490
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Perindopril
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|---|---|
| Legacy Concept Name |
Perindopril
|
| CHEBI_ID |
CHEBI:8024
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| Preferred_Name |
Perindopril
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| Semantic_Type |
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C72910
|
| DEFINITION |
A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
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| UMLS_CUI |
C0136123
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| code |
C72910
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| Chemical_Formula |
C19H32N2O5
|
| subClassOf | |
| type | |
| CAS_Registry |
82834-16-0
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| FULL_SYN |
Perindopril
(2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid, 1-ethyl Ester
PERINDOPRIL
S-9490
|
| FDA_UNII_Code |
Y5GMK36KGY
|
| Contributing_Source |
FDA
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| Concept_In_Subset | |
| Has_Salt_Form |
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