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National Cancer Institute Thesaurus
Last uploaded:
July 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72738
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72738
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|---|---|
| Preferred Name | Dexmedetomidine Hydrochloride |
| Definitions |
The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.
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| Synonyms |
Dexmedetomidine Hydrochloride
DEXMEDETOMIDINE HYDROCHLORIDE
Precedex
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Dexmedetomidine Hydrochloride
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|---|---|
| prefixIRI | Thesaurus:C72738
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| code | C72738
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| DEFINITION | The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.
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| CHEBI_ID | CHEBI:31472
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| Legacy Concept Name | Dexmedetomidine_Hydrochloride
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| PDQ_Open_Trial_Search_ID | 632933
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| Contributing_Source |
CTRP
FDA
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| PubMedID_Primary_Reference | 9227530
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| NCI_Drug_Dictionary_ID | 632933
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| FULL_SYN |
Dexmedetomidine Hydrochloride
DEXMEDETOMIDINE HYDROCHLORIDE
Precedex
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| Chemical_Formula | C13H16N2.HCl
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| UMLS_CUI | C0752310
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| FDA_UNII_Code | 1018WH7F9I
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| Preferred_Name | Dexmedetomidine Hydrochloride
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| type | |
| subClassOf | |
| Display_Name | Dexmedetomidine Hydrochloride
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| PDQ_Closed_Trial_Search_ID | 632933
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| Has_Free_Acid_Or_Base_Form | |
| CAS_Registry | 145108-58-3
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| Concept_In_Subset | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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