loading...| Preferred Name | Recombinant Oxytocin | |
| Synonyms |
Recombinant Oxytocin OXYTOCIN Oxytocin Pitocin Syntocinon |
|
| Definitions |
A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations. Increased calcium concentration levels activate myosin light chain kinase which, in turn, induces the formation of the contractile protein actomyosin. This stimulates uterine smooth muscle contractions. This agent also stimulates smooth muscles in the mammary glands, thereby causing lactation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C724 |
|
| CAS_Registry |
50-56-6 |
|
| CHEBI_ID |
CHEBI:7872 |
|
| Chemical_Formula |
C43H66N12O12S2 |
|
| code |
C724 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13236 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations. Increased calcium concentration levels activate myosin light chain kinase which, in turn, induces the formation of the contractile protein actomyosin. This stimulates uterine smooth muscle contractions. This agent also stimulates smooth muscles in the mammary glands, thereby causing lactation. |
|
| Display_Name |
Recombinant Oxytocin |
|
| FDA_UNII_Code |
1JQS135EYN |
|
| FULL_SYN |
Recombinant Oxytocin OXYTOCIN Oxytocin Pitocin Syntocinon |
|
| label |
Recombinant Oxytocin |
|
| Legacy Concept Name |
Therapeutic_Oxytocin |
|
| NCI_Drug_Dictionary_ID |
39293 |
|
| PDQ_Closed_Trial_Search_ID |
39293 |
|
| PDQ_Open_Trial_Search_ID |
39293 |
|
| Preferred_Name |
Recombinant Oxytocin |
|
| prefixIRI |
Thesaurus:C724 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0733348 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C724 | BERO | LOOM | |
| http://purl.bioontology.org/ontology/PDQ/CDR0000039293 | PDQ | LOOM |