Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Foscarnet | |
| Synonyms |
Phosphonoformate Phosphonoformic Acid Phosphonocarboxylic Acid Carboxyphosphonic Acid FOSCARNET Foscarnet |
|
| Definitions |
A synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Foscarnet selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the central nervous system. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71630 |
|
| CAS_Registry |
4428-95-9
|
|
| CHEBI_ID |
CHEBI:127780
|
|
| Chemical_Formula |
CH3O5P
|
|
| code |
C71630
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
|
|
| DEFINITION |
A synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Foscarnet selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the central nervous system.
|
|
| Display_Name |
Foscarnet
|
|
| FDA_UNII_Code |
364P9RVW4X
|
|
| FULL_SYN |
Phosphonoformate Phosphonoformic Acid Phosphonocarboxylic Acid Carboxyphosphonic Acid FOSCARNET Foscarnet
|
|
| Has_Salt_Form | ||
| label |
Foscarnet
|
|
| Legacy Concept Name |
Foscarnet_Base
|
|
| Preferred_Name |
Foscarnet
|
|
| prefixIRI |
Thesaurus:C71630
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0070895
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping