National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71629
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71629
Preferred Name

Fludrocortisone
Definitions
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion.
Synonyms
fludrocortisone
FLUDROCORTISONE
Fludrocortisone
Florinef
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Fludrocortisone
Legacy Concept Name
Fludrocortisone_Base
CHEBI_ID
CHEBI:50885
Preferred_Name
Fludrocortisone
Semantic_Type
Organic Chemical
Pharmacologic Substance
prefixIRI
Thesaurus:C71629
DEFINITION
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion.
UMLS_CUI
C0016280
code
C71629
Chemical_Formula
C21H29FO5
subClassOf
NSC Number
11318
type
CAS_Registry
127-31-1
FULL_SYN
fludrocortisone
FLUDROCORTISONE
Fludrocortisone
Florinef
FDA_UNII_Code
U0476M545B
ALT_DEFINITION
A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.
Contributing_Source
FDA
HemOnc
Concept_In_Subset
Has_Salt_Form
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