National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C712
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C712
Preferred Name

Ofloxacin
Definitions
A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04)
Synonyms
9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido(1,2,3-de)(1,4)benzoxazine-6-Carboxylic Acid, DL-
DL-8280
Floxin
HOE 280
OFLOXACIN
Ocuflox
Ofloxacin
ofloxacin
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Ofloxacin
Accepted_Therapeutic_Use_For
Various bacterial infections
Legacy Concept Name
Ofloxacin
CHEBI_ID
CHEBI:7731
NCI_Drug_Dictionary_ID
42865
PDQ_Closed_Trial_Search_ID
42865
Preferred_Name
Ofloxacin
Semantic_Type
Organic Chemical
Pharmacologic Substance
Antibiotic
prefixIRI
Thesaurus:C712
DEFINITION
A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04)
UMLS_CUI
C0028902
code
C712
Chemical_Formula
C18H20FN3O4
subClassOf
NSC Number
727071
type
CAS_Registry
82419-36-1
83380-47-6
FULL_SYN
9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido(1,2,3-de)(1,4)benzoxazine-6-Carboxylic Acid, DL-
DL-8280
Floxin
HOE 280
OFLOXACIN
Ocuflox
Ofloxacin
ofloxacin
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FDA_UNII_Code
A4P49JAZ9H
ALT_DEFINITION
An antibiotic drug used to treat infection. It belongs to the family of drugs called quinolone antibiotics.
PDQ_Open_Trial_Search_ID
42865
Contributing_Source
FDA
Concept_In_Subset
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