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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Myeloperoxidase | |
| Synonyms |
MYELOPEROXIDASE EC 1.11.1.7 Myeloperoxidase MPO |
|
| Definitions |
Myeloperoxidase (745 aa, ~84 kDa) is encoded by the human MPO gene. This protein is involved in the regulation of the innate host defense through the production of hypohalous acids. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71145 |
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| ALT_DEFINITION |
An antigen encoded by the MPO gene that regulates innate immunity through hypohalous acids production. It can be considered as an autoantigen and is commonly associated with autoimmune systemic vasculitis diseases, cystic fibrosis, COPD and other inflammatory conditions.
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|
| code |
C71145
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
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| Contributing_Source |
CDISC CTRP FDA
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| DEFINITION |
Myeloperoxidase (745 aa, ~84 kDa) is encoded by the human MPO gene. This protein is involved in the regulation of the innate host defense through the production of hypohalous acids.
|
|
| DesignNote |
Myeloperoxidase is synthesized as a single chain precursor that is cleaved into a light and heavy chain. The mature enzyme is a tetramer composed of 2 light chains and 2 heavy chains. (EntrezGene)
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|
| Display_Name |
Myeloperoxidase
|
|
| FDA_UNII_Code |
JQZ6YM58U5
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|
| FULL_SYN |
MYELOPEROXIDASE EC 1.11.1.7 Myeloperoxidase MPO
|
|
| label |
Myeloperoxidase
|
|
| Legacy Concept Name |
Myeloperoxidase
|
|
| OMIM_Number |
606989
|
|
| Preferred_Name |
Myeloperoxidase
|
|
| prefixIRI |
Thesaurus:C71145
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
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|
| Swiss_Prot |
P05164
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| UMLS_CUI |
C0027021
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| subClassOf |
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