National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Therapeutic Hemin
Synonyms

Hematin for Injection

Hemin for Injection

Therapeutic Hemin

Panhematin
Definitions

A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68925
code

C68925
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424
DEFINITION

A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.
FULL_SYN

Hematin for Injection

Hemin for Injection

Therapeutic Hemin

Panhematin
label

Therapeutic Hemin
Legacy Concept Name

Therapeutic_Hemin
NCI_Drug_Dictionary_ID

549706
PDQ_Closed_Trial_Search_ID

549706
PDQ_Open_Trial_Search_ID

549706
Preferred_Name

Therapeutic Hemin
prefixIRI

Thesaurus:C68925
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0030316
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471
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