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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C679
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C679
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|---|---|
| Preferred Name | Naltrexone Hydrochloride |
| Definitions |
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone.
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| Synonyms |
Naltrexone.HCl
naltrexone hydrochloride
NALTREXONE HYDROCHLORIDE
(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride
Naltrexone Hydrochloride
Depade
ReVia
Revia
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Naltrexone Hydrochloride
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|---|---|
| Legacy Concept Name |
Naltrexone
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| NCI_Drug_Dictionary_ID |
40818
|
| PDQ_Closed_Trial_Search_ID |
40818
|
| Preferred_Name |
Naltrexone Hydrochloride
|
| Display_Name |
Naltrexone Hydrochloride
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C679
|
| DEFINITION |
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone.
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| UMLS_CUI |
C0355800
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| code |
C679
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| Chemical_Formula |
C20H23NO4.HCl
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| subClassOf | |
| type | |
| CAS_Registry |
16676-29-2
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| FULL_SYN |
Naltrexone.HCl
naltrexone hydrochloride
NALTREXONE HYDROCHLORIDE
(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride
Naltrexone Hydrochloride
Depade
ReVia
Revia
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|
| FDA_UNII_Code |
Z6375YW9SF
|
| ALT_DEFINITION |
A drug that blocks the action of opiates (drugs used to treat pain). It may be used in the treatment of intravenous opiate addiction or alcohol dependence. Naltrexone hydrochloride is also being studied in the treatment of breast cancer. It may block the effects of the hormone estrogen, which causes some breast cancer cells to grow, or block the blood flow to tumors. It is a type of opiate antagonist.
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| PDQ_Open_Trial_Search_ID |
40818
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| Contributing_Source |
CTRP
FDA
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| Concept_In_Subset | |
| Has_Free_Acid_Or_Base_Form |
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