loading...| Preferred Name |
Naltrexone Hydrochloride |
|
| Synonyms |
Naltrexone.HCl naltrexone hydrochloride NALTREXONE HYDROCHLORIDE (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride Naltrexone Hydrochloride Depade ReVia Revia |
|
| Definitions |
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C679 |
|
| ALT_DEFINITION |
A drug that blocks the action of opiates (drugs used to treat pain). It may be used in the treatment of intravenous opiate addiction or alcohol dependence. Naltrexone hydrochloride is also being studied in the treatment of breast cancer. It may block the effects of the hormone estrogen, which causes some breast cancer cells to grow, or block the blood flow to tumors. It is a type of opiate antagonist. |
|
| CAS_Registry |
16676-29-2 |
|
| Chemical_Formula |
C20H23NO4.HCl |
|
| code |
C679 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone. |
|
| Display_Name |
Naltrexone Hydrochloride |
|
| FDA_UNII_Code |
Z6375YW9SF |
|
| FULL_SYN |
Naltrexone.HCl naltrexone hydrochloride NALTREXONE HYDROCHLORIDE (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride Naltrexone Hydrochloride Depade ReVia Revia |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Naltrexone Hydrochloride |
|
| Legacy Concept Name |
Naltrexone |
|
| NCI_Drug_Dictionary_ID |
40818 |
|
| PDQ_Closed_Trial_Search_ID |
40818 |
|
| PDQ_Open_Trial_Search_ID |
40818 |
|
| Preferred_Name |
Naltrexone Hydrochloride |
|
| prefixIRI |
Thesaurus:C679 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0355800 |
|
| subClassOf |