Colchicine-Site Binding Agent

Colchicine-Site Binding Agents

An anti-mitotic compound that binds to the beta tubulin subunit at the N-terminal domain (within residues 1-41) and within residues 214-241. Agents binding at the colchicine site produce a conformational change in the protofilament structure which subsequently impairs the polymerization of tubulin dimers and thereby prevents the formation of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, leading to cell cycle arrest and/or apoptosis.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67421

C67421

An anti-mitotic compound that binds to the beta tubulin subunit at the N-terminal domain (within residues 1-41) and within residues 214-241. Agents binding at the colchicine site produce a conformational change in the protofilament structure which subsequently impairs the polymerization of tubulin dimers and thereby prevents the formation of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, leading to cell cycle arrest and/or apoptosis.

Colchicine-Site Binding Agent

Colchicine-Site Binding Agents

Colchicine-Site Binding Agent

Colchicine-Site_Binding_Agent

Colchicine-Site Binding Agent

Thesaurus:C67421

Chemical Viewed Functionally

C1880116

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25974