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National Cancer Institute Thesaurus
Last uploaded:
June 2, 2026
| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66930
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66930
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| Preferred Name | Angiotensin II Receptor Antagonist |
| Definitions |
A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.
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| Synonyms |
Angiotensin II receptor blocker (ARB) medication
Angiotensin II Receptor Blocker
Angiotensin II Receptor Antagonist
Angiotensin II Receptor Antagonists
Angiotensin Receptor Blockers
ARB
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label | Angiotensin II Receptor Antagonist
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| prefixIRI | Thesaurus:C66930
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| code | C66930
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| DEFINITION | A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.
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| ALT_DEFINITION | An angiotensin receptor blocker (ARB) medication, a class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, among other actions. The combined effects result in reduction of blood pressure. It is primarily used for the treatment of hypertension or HF.
A pharmaceutical agent that selectively inhibits angiotensin II receptor activation in the renin-angiotensin-aldosterone system reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. It is primarily used for the reduction of proteinuria and the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.
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| Legacy Concept Name | Angiotensin_II_Receptor_Antagonist
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| Has_ACC-AHA_SARS2_Authorized_Value | |
| Contributing_Source |
ACC/AHA
NICHD
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| FULL_SYN |
Angiotensin II receptor blocker (ARB) medication
Angiotensin II Receptor Blocker
Angiotensin II Receptor Antagonist
Angiotensin II Receptor Antagonists
Angiotensin Receptor Blockers
ARB
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| UMLS_CUI | C0521942
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| Preferred_Name | Angiotensin II Receptor Antagonist
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| type | |
| subClassOf | |
| Concept_In_Subset |
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| Semantic_Type | Chemical Viewed Functionally
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