National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
Preferred Name

Spirapril Hydrochloride
Synonyms

Spirapril Hydrochloride

SPIRAPRIL HYDROCHLORIDE
Definitions

The hydrochloride salt form of spirapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spirapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66561
CAS_Registry

94841-17-5
Chemical_Formula

C22H30N2O5S2.HCl
code

C66561
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The hydrochloride salt form of spirapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spirapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
FDA_UNII_Code

OCC25LM897
FULL_SYN

Spirapril Hydrochloride

SPIRAPRIL HYDROCHLORIDE
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66560
label

Spirapril Hydrochloride
Legacy Concept Name

Spirapril_Hydrochloride
Preferred_Name

Spirapril Hydrochloride
prefixIRI

Thesaurus:C66561
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C1528843
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C247
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display