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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66117
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66117
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|---|---|
| Preferred Name | Methohexital Sodium |
| Definitions |
The sodium salt of methohexital, a rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.
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| Synonyms |
METHOHEXITAL SODIUM
Methohexital Sodium
Brevital
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Methohexital Sodium
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|---|---|
| Legacy Concept Name |
Methohexital_Sodium
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| CHEBI_ID |
CHEBI:6834
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| Preferred_Name |
Methohexital Sodium
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| Semantic_Type |
Pharmacologic Substance
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| prefixIRI |
Thesaurus:C66117
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| DEFINITION |
The sodium salt of methohexital, a rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.
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| UMLS_CUI |
C0304448
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| code |
C66117
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| Chemical_Formula |
C14H17N2O3.Na
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| subClassOf | |
| type | |
| CAS_Registry |
309-36-4
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| FULL_SYN |
METHOHEXITAL SODIUM
Methohexital Sodium
Brevital
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| FDA_UNII_Code |
60200PNZ7Q
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| Contributing_Source |
CPTAC
FDA
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| Concept_In_Subset |
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