National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Jump to:
Id http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66091
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66091
Preferred Name

Mephenytoin
Definitions
A heterocyclic organic compound with anticonvulsant property. Although the mechanism of action is not well established, mephenytoin potentially promotes sodium efflux from neurons in motor cortex, and stabilizes the threshold against hyperexcitability caused by excessive stimulation. Thus this agent reduces the membrane sodium gradient and prevents cortical seizure signal spreading. It may cause blood dyscrasias, therefore, this agent was only used after other less toxic anticonvulsants had failed.
Synonyms
MEPHENYTOIN
3-Ethylnirvanol
3-Methyl-5,5-phenylethylhydantoin
2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl-
Mephenytoin
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Mephenytoin
Legacy Concept Name
Mephenytoin
Preferred_Name
Mephenytoin
Semantic_Type
Pharmacologic Substance
prefixIRI
Thesaurus:C66091
DEFINITION
A heterocyclic organic compound with anticonvulsant property. Although the mechanism of action is not well established, mephenytoin potentially promotes sodium efflux from neurons in motor cortex, and stabilizes the threshold against hyperexcitability caused by excessive stimulation. Thus this agent reduces the membrane sodium gradient and prevents cortical seizure signal spreading. It may cause blood dyscrasias, therefore, this agent was only used after other less toxic anticonvulsants had failed.
UMLS_CUI
C0025381
code
C66091
Chemical_Formula
C12H14N2O2
subClassOf
NSC Number
34652
type
CAS_Registry
50-12-4
FULL_SYN
MEPHENYTOIN
3-Ethylnirvanol
3-Methyl-5,5-phenylethylhydantoin
2,4-Imidazolidinedione, 5-ethyl-3-methyl-5-phenyl-
Mephenytoin
FDA_UNII_Code
R420KW629U
Contributing_Source
FDA
Concept_In_Subset
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display