National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Levocetirizine

Synonyms

Levocetirizine

LEVOCETIRIZINE

Definitions

A third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66008

CAS_Registry

130018-77-8

Chemical_Formula

C21H25ClN2O3

code

C66008

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.

FDA_UNII_Code

6U5EA9RT2O

FULL_SYN

Levocetirizine

LEVOCETIRIZINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72814

label

Levocetirizine

Legacy Concept Name

Levocetirizine

NCI_Drug_Dictionary_ID

742652

PDQ_Closed_Trial_Search_ID

742652

PDQ_Open_Trial_Search_ID

742652

Preferred_Name

Levocetirizine

prefixIRI

Thesaurus:C66008

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1174893

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29578

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