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National Cancer Institute Thesaurus
| Preferred Name | Plicamycin | |
| Synonyms |
Mithramycin Aureolic acid mithramycin A-2371 MTH Mithracin Mithracine PA-144 PLICAMYCIN Plicamycin plicamycin |
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| Definitions |
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C658 |
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| ALT_DEFINITION |
A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.
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| CAS_Registry |
18378-89-7
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| CHEBI_ID |
CHEBI:31856
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| Chemical_Formula |
C52H76O24
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|
| code |
C658
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc
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|
| DEFINITION |
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)
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|
| Display_Name |
Plicamycin
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|
| FDA_UNII_Code |
NIJ123W41V
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|
| FULL_SYN |
Mithramycin Aureolic acid mithramycin A-2371 MTH Mithracin Mithracine PA-144 PLICAMYCIN Plicamycin plicamycin
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|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Plicamycin
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|
| Legacy Concept Name |
Plicamycin
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|
| Maps_To |
Plicamycin
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| NCI_Drug_Dictionary_ID |
41738
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| NSC Number |
24559
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| PDQ_Closed_Trial_Search_ID |
41738
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| PDQ_Open_Trial_Search_ID |
41738
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| Preferred_Name |
Plicamycin
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|
| prefixIRI |
Thesaurus:C658
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0026234
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| subClassOf |
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