Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Fosinopril | |
| Synonyms |
FOSINOPRIL Fosinopril |
|
| Definitions |
A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65761 |
|
| CAS_Registry |
98048-97-6
|
|
| CHEBI_ID |
CHEBI:5163
|
|
| Chemical_Formula |
C30H46NO7P
|
|
| code |
C65761
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow.
|
|
| FDA_UNII_Code |
R43D2573WO
|
|
| FULL_SYN |
FOSINOPRIL Fosinopril
|
|
| Has_Salt_Form | ||
| label |
Fosinopril
|
|
| Legacy Concept Name |
Fosinopril
|
|
| Preferred_Name |
Fosinopril
|
|
| prefixIRI |
Thesaurus:C65761
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0118168
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping