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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65513
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65513
|
|---|---|
| Preferred Name | Entecavir |
| Definitions |
A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.
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| Synonyms |
9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)Guanine Monohydrate
BMS-200475-01
6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)- Monohydrate
Baraclude
ENTECAVIR
ETV
Entecavir
SQ-34676
SQ34676
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Entecavir
|
|---|---|
| Legacy Concept Name |
Entecavir
|
| CHEBI_ID |
CHEBI:59902
|
| NCI_Drug_Dictionary_ID |
617986
|
| PDQ_Closed_Trial_Search_ID |
617986
|
| Preferred_Name |
Entecavir
|
| Semantic_Type |
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C65513
|
| DEFINITION |
A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.
|
| UMLS_CUI |
C0971023
|
| code |
C65513
|
| Chemical_Formula |
C12H15N5O3.H2O
|
| subClassOf | |
| type | |
| CAS_Registry |
209216-23-9
|
| FULL_SYN |
9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)Guanine Monohydrate
BMS-200475-01
6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)- Monohydrate
Baraclude
ENTECAVIR
ETV
Entecavir
SQ-34676
SQ34676
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|
| FDA_UNII_Code |
5968Y6H45M
|
| PDQ_Open_Trial_Search_ID |
617986
|
| Contributing_Source |
FDA
|
| Concept_In_Subset |
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