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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Id | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65364
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65364
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|---|---|
| Preferred Name | Darunavir |
| Definitions |
A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication.
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| Synonyms |
(3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate
DARUNAVIR
Darunavir
TMC114
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Darunavir
|
|---|---|
| Legacy Concept Name |
Darunavir
|
| CHEBI_ID |
CHEBI:367163
|
| Preferred_Name |
Darunavir
|
| Semantic_Type |
Pharmacologic Substance
|
| prefixIRI |
Thesaurus:C65364
|
| DEFINITION |
A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication.
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| UMLS_CUI |
C1435444
|
| code |
C65364
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| Chemical_Formula |
C27H37N3O7S
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| subClassOf | |
| type | |
| CAS_Registry |
206361-99-1
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| FULL_SYN |
(3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate
DARUNAVIR
Darunavir
TMC114
|
| FDA_UNII_Code |
YO603Y8113
|
| Contributing_Source |
FDA
|
| Concept_In_Subset |
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